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Opioid-Induced Constipation (OIC)—a unique form of constipation

Opioid Induced Constipation graphic

Opioids block pain signals in the brain and other parts of the central nervous system, by attaching to something called mu-receptors. But when opioids attach to mu-receptors in the bowel, they can cause OIC.

Opioid-induced constipation (OIC) is one of the most common side effects of opioid use, and can last for the length of treatment.

“After my back injury, opioids helped with the chronic pain, but backed me up — big time.

Opioid-Induced Constipation (OIC)—a unique form of constipation

Opioids block pain signals in the brain and other parts of the central nervous system, by attaching to something called mu-receptors. But when opioids attach to mu-receptors in the bowel, they can cause OIC.

Opioid-induced constipation (OIC) is one of the most common side effects of opioid use, and can last for the length of treatment.

"I tried many things, but when the constipation wouldn't go away, I talked to my doctor."

IMPORTANT SAFETY INFORMATION ABOUT MOVANTIK

IMPORTANT SAFETY INFORMATION ABOUT MOVANTIK

  • MOVANTIK may cause serious side effects, including:
    • Opioid withdrawal. You may have symptoms of opioid withdrawal during treatment with MOVANTIK, including sweating, chills, diarrhea, stomach pain, anxiety, irritability, and yawning. Patients taking methadone to treat their pain may be more likely to experience stomach pain and diarrhea. Tell your doctor if you have any of these symptoms
    • Severe Stomach Pain and/or Diarrhea. This can happen within a few days of starting MOVANTIK and can lead to hospitalization. If either of these side effects occurs, stop taking MOVANTIK and call your doctor immediately
    • Tear in your stomach or intestinal wall (perforation). Stomach pain that is severe can be a sign of a serious medical condition. If you get stomach pain that gets worse or does not go away, stop taking MOVANTIK and get emergency medical help right away
  • Do not take MOVANTIK if you:
    • Have a bowel blockage (intestinal obstruction) or have a history of bowel blockage
    • Are allergic to MOVANTIK or any of the ingredients in MOVANTIK
  • MOVANTIK can interact with other medicines and cause side effects, including opioid withdrawal symptoms (see symptoms above). Tell your doctor or pharmacist before you start or stop any medicines during treatment with MOVANTIK
  • Before taking MOVANTIK, tell your doctor right away if you are:
    • Pregnant or plan to become pregnant. Taking MOVANTIK during pregnancy may cause opioid withdrawal symptoms in your unborn baby. Tell your doctor right away if you become pregnant during treatment with MOVANTIK
    • Breastfeeding or plan to breastfeed. It is not known if MOVANTIK passes into your breast milk. Taking MOVANTIK while you are breastfeeding may cause opioid withdrawal in your baby. You and your doctor should decide if you will take MOVANTIK or breastfeed. You should not breastfeed while taking MOVANTIK
  • Tell your health care provider if you are pregnant or plan to become pregnant during treatment with MOVANTIK
  • Tell your doctor about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Other medicines may affect the way MOVANTIK works
  • If you stop taking your opioid pain medicine, stop taking MOVANTIK and tell your doctor
  • Avoid eating grapefruit or drinking grapefruit juice during treatment with MOVANTIK
  • The most common side effects of MOVANTIK include: Stomach (abdomen) pain, diarrhea, nausea, gas, vomiting, headache, and excessive sweating

APPROVED USE FOR MOVANTIK

MOVANTIK is a prescription medicine used to treat constipation that is caused by prescription pain medicines called opioids, in adults with long-lasting (chronic) pain that is not caused by cancer.

MOVANTIK is a prescription medicine used to treat constipation caused by prescription pain medicines called opioids, in adults with long-lasting (chronic) pain not caused by cancer.

Click here for the Medication GuideMedication Guide and full Prescribing InformationPrescribing Information for MOVANTIK.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088. 1-800-FDA-1088.

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