When administered at the recommended dose levels, once-daily MOVANTIK functions as a PAMORA in tissues such as the bowel, thereby decreasing the constipating effects of opioids2
CNS=central nervous system; PAMORA=peripherally acting mu-opioid receptor antagonist.
References: 1. Brock C, Olesen SS, Olesen AE, Frøkjaer JB, Andresen T, Drewes AM. Opioid-induced bowel dysfunction: pathophysiology and management. Drugs. 2012;72:1847-1865. 2. MOVANTIK® (naloxegol) [prescribing information]. Wilmington, DE: AstraZeneca Pharmaceuticals LP; 2018.
MOVANTIK is a prescription medicine used to treat constipation that is caused by prescription pain medicines called opioids, in adults with long-lasting (chronic) pain that is not caused by active cancer.