
Why MOVANTIK?
When opioids attach to something called mu-receptors in your bowel, they can cause OIC.
Once-daily MOVANTIK is specifically designed for OIC, and may help you go more often by blocking opioids from binding to these receptors in your bowel.

How fast does MOVANTIK work?
In clinical studies, MOVANTIK worked quickly, often within 6 to 12 hours of the first dose.

How is once-daily MOVANTIK taken?
Take MOVANTIK exactly as your health care provider tells you
Take your prescribed dose of MOVANTIK one time each day, on an empty stomach, at least 1 hour before your first meal of the day or 2 hours after the meal
Stop taking other laxatives before you start treatment with MOVANTIK. Your health care provider may prescribe other laxatives if MOVANTIK does not work after 3 days of treatment
MOVANTIK has been shown to be effective in people who have taken opioid pain medicines for at least 4 weeks
Tell your health care provider if you stop taking your opioid pain medicine. If you stop taking your opioid pain medicine, you should also stop taking MOVANTIK
If you take too much MOVANTIK, call your health care provider or go to the nearest emergency room right away
What should I avoid while taking MOVANTIK?
What should I tell my health care provider before taking MOVANTIK?
Before you take MOVANTIK, tell your health care provider about all of your medical conditions, including if you:
have any stomach or bowel (intestines) problems, including stomach ulcer, Crohn’s disease, diverticulitis, cancer of the stomach or bowel, or Ogilvie’s syndrome
have kidney problems
have liver problems
are pregnant or plan to become pregnant. Taking MOVANTIK during pregnancy may cause opioid withdrawal symptoms in you or your unborn baby. Tell your health care provider right away if you become pregnant during treatment with MOVANTIK
are breastfeeding or plan to breastfeed. It is not known if MOVANTIK passes into your breast milk
taking MOVANTIK while you are breastfeeding may cause opioid withdrawal in your baby. You and your health care provider should decide if you will take MOVANTIK or breastfeed. You should not breastfeed if you take MOVANTIK
Who should not take MOVANTIK?
Do not take MOVANTIK if you:
MOVANTIK can interact with certain other medicines and cause side effects, including opioid withdrawal symptoms such as sweating, chills, diarrhea, stomach pain, anxiety, irritability, and yawning. Tell your health care provider or pharmacist before you start or stop any medicines during treatment with MOVANTIK.

What are the possible side effects of MOVANTIK?
MOVANTIK may cause serious side effects, including:
Opioid withdrawal. You may have symptoms of opioid withdrawal during treatment with MOVANTIK including sweating, chills, diarrhea, stomach pain, anxiety, irritability, and yawning. If you take methadone to treat your pain, you may be more likely to have stomach pain and diarrhea than people who do not take methadone. Tell your health care provider if you have any of these symptoms
Severe stomach pain or diarrhea, or both severe stomach pain and diarrhea. Severe stomach pain and diarrhea can happen when you take MOVANTIK. These problems can happen within a few days after you start taking MOVANTIK and can lead to hospitalization. Stop taking MOVANTIK and call your health care provider right away if you have severe stomach pain or diarrhea, or both severe stomach pain and diarrhea
Tear in your stomach or intestinal wall (perforation). Stomach pain that is severe can be a sign of a serious medical condition. If you have stomach pain that gets worse or does not go away, stop taking MOVANTIK and get emergency medical help right away
The most common side effects of MOVANTIK include: stomach (abdomen) pain, diarrhea, nausea, gas, vomiting, and headache.
Tell your health care provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of MOVANTIK.
Call your doctor for medical advice about side effects.
You may report side effects related to AstraZeneca products by clicking here.
Please see Important Safety Information and Medication Guide and US Full Prescribing Information.