How is once-daily MOVANTIK taken?

• Take MOVANTIK exactly as your health care provider tells you

• Take your prescribed dose of MOVANTIK one time each day, on an empty stomach, at least 1 hour before your first meal of the day or 2 hours after the meal

• Stop taking other laxatives before you start treatment with MOVANTIK. Your health care provider may prescribe other laxatives if MOVANTIK does not work after 3 days of treatment

• MOVANTIK has been shown to be effective in people who have taken opioid pain medicines for at least 4 weeks

• Tell your health care provider if you stop taking your opioid pain medicine. If you stop taking your opioid pain medicine, you should also stop taking MOVANTIK

• If you take too much MOVANTIK, call your health care provider or go to the nearest emergency room right away

What should I avoid while taking MOVANTIK?

• Avoid eating grapefruit or drinking grapefruit juice during treatment with MOVANTIK

What should I tell my health care provider before taking MOVANTIK?

Before you take MOVANTIK, tell your health care provider about all of your medical conditions, including if you:

• have any stomach or bowel (intestines) problems, including stomach ulcer, Crohn’s disease, diverticulitis, cancer of the stomach or bowel, or Ogilvie’s syndrome

• have kidney problems

• have liver problems

• are pregnant or plan to become pregnant. Taking MOVANTIK during pregnancy may cause opioid withdrawal symptoms in you or your unborn baby. Tell your health care provider right away if you become pregnant during treatment with MOVANTIK

• are breastfeeding or plan to breastfeed. It is not known if MOVANTIK passes into your breast milk

• taking MOVANTIK while you are breastfeeding may cause opioid withdrawal in your baby. You and your health care provider should decide if you will take MOVANTIK or breastfeed. You should not breastfeed if you take MOVANTIK

Tell your health care provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Other medicines may affect the way MOVANTIK works.

Who should not take MOVANTIK?

Do not take MOVANTIK if you:

• have a bowel blockage (intestinal obstruction) or have a history of bowel blockage

• are allergic to MOVANTIK or any of the ingredients in MOVANTIK

MOVANTIK can interact with certain other medicines and cause side effects, including opioid withdrawal symptoms such as sweating, chills, diarrhea, stomach pain, anxiety, irritability, and yawning. Tell your health care provider or pharmacist before you start or stop any medicines during treatment with MOVANTIK.