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How once-daily MOVANTIK works

How MOVANTIK works

Once-daily MOVANTIK may help you go more often by blocking opioids from binding to mu-receptors in the bowel.

In clinical studies, MOVANTIK worked quickly, often within 6 to 12 hours of the first dose.

FOR ADULTS WITH CHRONIC NON-CANCER PAIN

How once-daily MOVANTIK works plus-icon

How MOVANTIK works
How MOVANTIK works

Once-daily MOVANTIK may help you go more often by blocking opioids from binding to mu-receptors in the bowel.

In clinical studies, MOVANTIK worked quickly, often within 6 to 12 hours of the first dose.

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"Finally, I let it out and told my doctor." Have your MOVANTIK Moment. Talk to your doctor.

IMPORTANT SAFETY INFORMATION ABOUT MOVANTIK

IMPORTANT SAFETY INFORMATION ABOUT MOVANTIK

  • MOVANTIK may cause serious side effects, including:
    • Opioid withdrawal. You may have symptoms of opioid withdrawal during treatment with MOVANTIK, including sweating, chills, diarrhea, stomach pain, anxiety, irritability, and yawning. Patients taking methadone to treat their pain may be more likely to experience stomach pain and diarrhea. Tell your doctor if you have any of these symptoms
    • Severe Stomach Pain and/or Diarrhea. This can happen within a few days of starting MOVANTIK and can lead to hospitalization. If either of these side effects occurs, stop taking MOVANTIK and call your doctor immediately
    • Tear in your stomach or intestinal wall (perforation). Stomach pain that is severe can be a sign of a serious medical condition. If you get stomach pain that gets worse or does not go away, stop taking MOVANTIK and get emergency medical help right away
  • Do not take MOVANTIK if you:
    • Have a bowel blockage (intestinal obstruction) or have a history of bowel blockage
    • Are allergic to MOVANTIK or any of the ingredients in MOVANTIK
  • MOVANTIK can interact with other medicines and cause side effects, including opioid withdrawal symptoms (see symptoms above). Tell your doctor or pharmacist before you start or stop any medicines during treatment with MOVANTIK
  • Before taking MOVANTIK, tell your doctor right away if you are:
    • Pregnant or plan to become pregnant. Taking MOVANTIK during pregnancy may cause opioid withdrawal symptoms in your unborn baby. Tell your doctor right away if you become pregnant during treatment with MOVANTIK
    • Breastfeeding or plan to breastfeed. It is not known if MOVANTIK passes into your breast milk. Taking MOVANTIK while you are breastfeeding may cause opioid withdrawal in your baby. You and your doctor should decide if you will take MOVANTIK or breastfeed. You should not breastfeed while taking MOVANTIK
  • Tell your health care provider if you are pregnant or plan to become pregnant during treatment with MOVANTIK
  • Tell your doctor about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Other medicines may affect the way MOVANTIK works
  • If you stop taking your opioid pain medicine, stop taking MOVANTIK and tell your doctor
  • Avoid eating grapefruit or drinking grapefruit juice during treatment with MOVANTIK
  • The most common side effects of MOVANTIK include: Stomach (abdomen) pain, diarrhea, nausea, gas, vomiting, headache, and excessive sweating

APPROVED USE FOR MOVANTIK

MOVANTIK is a prescription medicine used to treat constipation that is caused by prescription pain medicines called opioids, in adults with long-lasting (chronic) pain that is not caused by active cancer.

MOVANTIK is a prescription medicine used to treat constipation caused by prescription pain medicines called opioids, in adults with long-lasting (chronic) pain not caused by active cancer.

Click here for the Medication GuideMedication Guide and full Prescribing InformationPrescribing Information for MOVANTIK.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088. 1-800-FDA-1088.

AstraZeneca supports the responsible use of medications, including those containing opioids, as treatment options for patients with chronic non-cancer pain.

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